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BAY 80-6946
CAS No. 1032568-63-0
BAY 80-6946 ( Copanlisib )
Catalog No. M10156 CAS No. 1032568-63-0
BAY 80-6946 (Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM. Phase 2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 65 | In Stock |
|
| 25MG | 115 | In Stock |
|
| 50MG | 200 | In Stock |
|
| 100MG | 335 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBAY 80-6946
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NoteResearch use only, not for human use.
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Brief DescriptionBAY 80-6946 (Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM. Phase 2.
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DescriptionBAY 80-6946 (Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM. Phase 2.
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In Vitro——
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In VivoAnimal Model:Athymic nude rats injected with KPL4 tumor cells Dosage:0.5 mg/kg, 1 mg/kg, 3 mg/kg or 6 mg/kg.Administration:Intravenous injection; every second day, every third day; for 60 days Result:On day 25, tumor growth inhibition (TGI) rates of 77%, 84%, 99%, and 100% were observed at doses of 0.5, 1, 3, and 6 mg/kg, respectively. All rats remained tumor free at the termination of the study on day 73.
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SynonymsCopanlisib
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα| PI3Kβ| PI3Kγ| PI3Kδ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1032568-63-0
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Formula Weight480.52
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Molecular FormulaC23H28N8O4
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Purity>98% (HPLC)
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SolubilityDMSO:0.002 mg/mL (0.0 mM); Ethanol:0.01 mg/mL (0.02 mM); Water:0.002 mg/mL
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SMILESCOC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Patnaik A, et al. J Clin Oncol, 29, 2011, (suppl, abstr 3035)
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